Magdalena Biosciences Unveils Promising Preclinical Study Results on Coca Extract

Jaguar Health Inc. announced positive results from a preclinical study conducted by Magdalena Biosciences, a joint venture between Jaguar and Filament Health Corp. The study shows that a novel extract from coca leaves prevented weight gain in mice on a high-fat diet, without altering their food intake or physical activity. The extract is developed as a drug candidate for managing weight loss post-GLP-1 medication, following FDA’s Botanical Guidance.

The research aims to address weight gain occurring after stopping GLP-1 treatments, which typically reduce appetite. Indications suggest the coca leaf extract could potentially provide a safe, long-term weight maintenance therapy. Provided by Empresa Nacional de La Coca, the coca used in the study ties back to traditional practices in the Andean regions.

The study's promising outcomes suggest natural plant-derived medicines could offer effective solutions with potentially fewer side effects than synthetic drugs. Further development could promote the beneficial integration of traditional Andean knowledge into modern pharmacology.